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human integrin β1 sirna  (Shanghai GenePharma)

 
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    Shanghai GenePharma human integrin β1 sirna
    Human Integrin β1 Sirna, supplied by Shanghai GenePharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human integrin β1 sirna/product/Shanghai GenePharma
    Average 90 stars, based on 1 article reviews
    human integrin β1 sirna - by Bioz Stars, 2026-03
    90/100 stars

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    A. Increasing matrix stiffness upregulates the phosphorylation levels of Akt and mTOR, as well as the expressions of mTOR downstream molecules p-4E-BP and SOX2 in two HCC cells. B. Integrin β1 knockdown suppresses the phosphorylation level of Akt and mTOR, attenuates p-4E-BP and SOX2 expression in two HCC cells, while rapamycin, an mTOR-inhibitor, not only results in an obvious decrease of mTOR phosphorylation level and its downstream molecules expression, but also produces a slight increase in AKT phosphorylation level.

    Journal: Oncotarget

    Article Title: Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells

    doi: 10.18632/oncotarget.8515

    Figure Lengend Snippet: A. Increasing matrix stiffness upregulates the phosphorylation levels of Akt and mTOR, as well as the expressions of mTOR downstream molecules p-4E-BP and SOX2 in two HCC cells. B. Integrin β1 knockdown suppresses the phosphorylation level of Akt and mTOR, attenuates p-4E-BP and SOX2 expression in two HCC cells, while rapamycin, an mTOR-inhibitor, not only results in an obvious decrease of mTOR phosphorylation level and its downstream molecules expression, but also produces a slight increase in AKT phosphorylation level.

    Article Snippet: Small interfering RNAs (siRNAs) targeting the human integrin β1 gene were designed by the Shanghai GeneChem, Co., Ltd., China.

    Techniques: Expressing

    Schematic diagram of the proposed mechanism by which matrix stiffness drives integrin β1/Akt/mTOR/SOX2 signaling pathway to regulate the stemness characteristics of HCC

    Journal: Oncotarget

    Article Title: Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells

    doi: 10.18632/oncotarget.8515

    Figure Lengend Snippet: Schematic diagram of the proposed mechanism by which matrix stiffness drives integrin β1/Akt/mTOR/SOX2 signaling pathway to regulate the stemness characteristics of HCC

    Article Snippet: Small interfering RNAs (siRNAs) targeting the human integrin β1 gene were designed by the Shanghai GeneChem, Co., Ltd., China.

    Techniques: